What is the Endocannabinoid System?
In order to understand the CBD benefit and how CBD interacts with the human body, it is crucial to explain how the endocannabinoid system in our bodies work. The endocannabinoid system is a biological system that is composed of endogenous lipid-based retrograde neurotransmitters called endocannabinoid. Furthermore, these lipids bind to cannabinoid receptors, and cannabinoid receptor proteins that are expressed throughout the central and peripheral nervous system including the brain.
The system plays a crucial role in regulating physiological and cognitive processes such as:
- Prenatal development
- Postnatal development.
The system also go to work after physical exercise. It releases euphoria; a controlling element that help regulate the locomotor activity.
In summary, the system plays a role in regulating and balancing your body from outside influences. Stress and other things like exercise creates an imbalance and the system is responsible for returning your body to the initial state.
Endocannabinoid System Receptors: CB1, CB2.
The CB1 Receptor
The CB1 receptor is located in the: brain, nervous system, peripheral organs, intestines, and tissues. It was first discovered in 1990. The primary role of CB1 receptors is to inhibit neurotransmitter release. THC, due to its molecular structure interacts well with this receptor. Since CB1 receptors are also located in the brain, that explains the feeling of a ‘high‘ when consuming THC. CBD on the other hand doesn’t interact directly with this receptor; it mainly interacts with CB2 instead.
The CB2 Receptor
The CB2 receptor has another set of responsibilities. These receptors are mostly found in white blood cells, tonsils, and the spleen; only a small number exists in the brain. They play an important role in the regulation of cytokine release. According to the US National Library of Medicine, cytokine help in meditating and regulating the immunity, inflammation, and hematopoiesis. Also, activating the CB2 receptor induces macrophages to destroy the beta-amyloid protein which is the main component of the plaque found in the brains of people with Alzheimer’s disease.
The body makes its own cannabinoid called 2-AG. However, external factors such as stress can hinder the process. That’s where CBD comes in.
CBD interacts very well with the CB2 receptor; it binds with it so well that it makes you consider whether CBD exists to bind with it. In fact, hemp oil was used in food since 6000 BCE. Also, Carl Sagan in 1977 touched on the point that cannabis may possible be the world’s fist agricultural crop.
So How Would CBD Help?
CBD stimulates the Endocannabinoid System. It helps with decreasing inflammation and works on reducing the sensation of pain. The following are some benefits of CBD:
- Helping control IBS
- Aiding in decreasing withdrawal symptoms from substance abuse
- Improves concentration
- Decreasing anxiety
- Combats depression
- Reducing acne
- Fights Inflammation
- Combats bacterial infections
- Reducing nausea
- Decreasing symptoms of depression
- Maintaining normal blood pressure
- Decreasing fear and paranoia
- Promoting skin health
- Fighting malignant cell growth
- Promoting good bone health
- Alleviated pain and related discomforts
- Aiding in kidney function
Although our bodies produce endocannabinoid already, the production can be impaired by things we do to our bodies. Things like stress, exercise, etc affect the system. This explains why certain people can feel more depressed than others. It also shows why some people are more active than others. An outside source of CBD can help our endocannabinoid go back on track. It helps it return to full function or even above full functionality. This will lead to an all-around healthier and more fulfilled lifestyle.